Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of GALNT1 inhibited EGF-induced migration and invasion.
|
25730904 |
2015 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
|
29136499 |
2017 |
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To attempt to inhibit the synthesis of O-glycan, we transfected antisense cDNA of GalNAc transferase type 1 (GalNAc-T1) into a human gastric cancer cell line, JRST.
|
9300683 |
1997 |
Regurgitation
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In the adult mouse, compromised cardiac function that mimics human congenital heart disease, including aortic and pulmonary valve stenosis and regurgitation; altered ejection fraction; and cardiac dilation, was observed in Galnt1 null animals.
|
25615642 |
2015 |
Pulmonary Valve Stenosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the adult mouse, compromised cardiac function that mimics human congenital heart disease, including aortic and pulmonary valve stenosis and regurgitation; altered ejection fraction; and cardiac dilation, was observed in Galnt1 null animals.
|
25615642 |
2015 |
Pulmonary Stenosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the adult mouse, compromised cardiac function that mimics human congenital heart disease, including aortic and pulmonary valve stenosis and regurgitation; altered ejection fraction; and cardiac dilation, was observed in Galnt1 null animals.
|
25615642 |
2015 |
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
To attempt to inhibit the synthesis of O-glycan, we transfected antisense cDNA of GalNAc transferase type 1 (GalNAc-T1) into a human gastric cancer cell line, JRST.
|
9300683 |
1997 |
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
|
29136499 |
2017 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, GALNT1 is a potential target in HCC.
|
25730904 |
2015 |
Hemorrhagic Fever, Ebola
|
0.010 |
Biomarker
|
disease |
BEFREE |
Site-specific glycosylation of Ebola virus glycoprotein by human polypeptide GalNAc-transferase 1 induces cell adhesion defects.
|
30389789 |
2018 |
Heart Valve Prolapse
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
Heart valve disease
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have elucidated a novel miR-30-GALNT1/2 axis whose dysregulation increases the proportion of inactive proBNP secreted by the heart and impairs the compensatory actions of BNP during the progression of heart failure.
|
28188250 |
2017 |
Epithelial ovarian cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.
|
20142253 |
2010 |
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have elucidated a novel miR-30-GALNT1/2 axis whose dysregulation increases the proportion of inactive proBNP secreted by the heart and impairs the compensatory actions of BNP during the progression of heart failure.
|
28188250 |
2017 |
Congenital heart disease
|
0.010 |
Biomarker
|
group |
BEFREE |
In the adult mouse, compromised cardiac function that mimics human congenital heart disease, including aortic and pulmonary valve stenosis and regurgitation; altered ejection fraction; and cardiac dilation, was observed in Galnt1 null animals.
|
25615642 |
2015 |
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SNHG7 positively regulated GALNT1 level through sponging miR-216b, and played an oncogenic role in CRC progression.
|
29915311 |
2018 |
Child Development Disorders, Pervasive
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Identification of common genetic risk variants for autism spectrum disorder.
|
30804558 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.
|
20142253 |
2010 |
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the effect of glycopeptide-preferring polypeptide GalNAc transferase 1 (ppGalNAc T1) targeted RNA interference (RNAi) on the growth and migration of human bladder carcinoma EJ cells in vitro and in vivo.
|
23317233 |
2012 |